After the first two games went extra innings -- spanning a total of 28 frames in two contests -- the two teams will square off in the series finale on Sunday at Progressive Field.
The finale -- the Blue Jays are looking to get out of Cleveland with a three-game sweep -- pits two pitchers at very different stages of their big league careers.
In one dugout, 38-year-old veteran Derek Lowe will open his 16th big league season and return to the American League after spending the last seven years with the Dodgers and Braves.
On the other side of the field, Blue Jays starter Joel Carreno earned a rotation spot to start the season. The right-hander has just 15 2/3 innings of big league experience.
"I have to do a good job for them," Carreno said about his opportunity. "I don't [want] to make them think, 'He has to go back to the Minor Leagues.' So I have to do the best I can do here."
Lowe last threw on Tuesday, in Cleveland's 13-0 exhibition win against Class A Carolina. He struck out three and allowed one hit in three solid innings.
Lowe has been battling a minor back issue, but said he firmly believes it won't hold him back. He left a late March outing early, but said it's more of a cramp than anything more serious.
"It was like my whole right side was just not my friend," Lowe said. "In hindsight, I probably should've just stopped after the first inning. But I told them, 'You pitch through stuff all the time,' and I said, 'It's not going to get any worse and it's not going to get any better.'"
Blue Jays: Work in progress
Carreno appeared in 11 games for Toronto last year, but will be making his first career start on Sunday. He had a 1.15 ERA, allowing 11 hits in 15 2/3 innings while striking out 14. He said he spent some time in the Minors working on a few of his pitches, and is prepared to be available for the rotation or out of the bullpen.
"I'm working on my changeup and my front side," Carreno said. "Sometimes I go side to side with my pitches and my pitches fly into the strike zone, and the hitters take advantage of those pitches."
Blue Jays right fielder Jose Bautista went 0-for-4 on Saturday, but is still hitting .375 at the early stages of the season.
Indians: Bullpen getting in work
Due to the lengthy nature of the first two games of the season, the Indians' bullpen has already had plenty of opportunities. Five pitchers threw after starter Justin Masterson on Thursday (Chris Perez, Vinnie Pestano, Joe Smith, Tony Sipp and Jairo Asencio), combining to allow eight hits and six runs in eight innings.
Saturday, the Indians used six relievers (Smith, Pestano, Rafael Perez, Chris Perez, Sipp and Dan Wheeler) who combined for five earned runs in five innings.
After taking the blown save on Opening Day -- allowing three hits, two walks and three earned runs in 2/3 of an inning -- Indians closer Chris Perez bounced back nicely Saturday with a shutout inning.
The Blue Jays won four of the seven meetings between the two clubs last season, outscoring the Indians, 50-37.