Lincecum will attempt to improve his 1-2 record and 8.20 ERA on Saturday as the Giants host the Padres in the second contest of a three-game set.
The righty will be matched by San Diego's Anthony Bass. The righty is coming from quite the different corner than Lincecum. While it will be Bass' fourth start of the year, the 24-year-old has seen action in six games, as he started the season in the bullpen. But injuries to Tim Stauffer (elbow strain) and Dustin Moseley (season-ending labrum tear) forced the Padres to move Bass to the rotation.
"Overall, we've been happy with his work," Padres manager Bud Black said. "With him, it's just the efficiency and making the most of his pitches. He needs to throw every pitch with a purpose and make it a quality pitch. That's his challenge moving forward."
Bass picked up his first win of the season in his last outing, pitching six innings of three-hit ball, striking out seven and allowing just one unearned run.
Giants: Hacker recalled from Triple-A, gets start
The Giants purchased the contract of right-hander Eric Hacker from Triple-A Fresno on Friday. Hacker made his first Major League start later that day and was tagged with the loss, giving up three runs on eight hits while striking out seven in six innings of work. To make room on the 25-man roster, the Giants sent righty Dan Otero to Fresno and moved reliever Brian Wilson to the 60-day disabled list to clear a spot on the 40-man roster for Hacker.
Pablo Sandoval extended his Major League-leading hitting streak to 20 games with a single in the third inning of Friday's 5-3 loss to the Padres. Sandoval's career-high hitting streak is 22 games.
Padres: Hits keep coming for Headley
After a 1-for-4 performance Friday, Chase Headley has now hit safely in 16 of the last 18 games. He is hitting .323 (20-for-62) during that stretch.
Orlando Hudson extended his hitting streak to 10 games with a fourth-inning single in Friday's win over the Giants. It is the longest hitting streak by a Padres player this season.
The Giants have won 11 of the last 15 meetings against the Padres, a streak that dates back to last season.
The Padres improved to 2-5 in series openers after their win over the Giants. San Francisco dropped to 3-4 in series openers.