After all, following Monday's doubleheader, which the Tribe swept, the teams have already met seven times this season. They'll play twice more in Cleveland this week and three more times in Chicago toward the end of the month.
"It's weird to play them this often," said White Sox skipper Robin Ventura. "We've already been here once. It just seems odd. You expect that to be spaced out, and now we're playing again and we don't play them again until the end of the year. It's just a weird schedule, but I didn't make it."
Tuesday's meeting will be a matchup of pitchers who have already squared off twice this season, including last Thursday at U.S. Cellular Field. Both hurlers -- expected to anchor their respective rotations this season -- have gotten off to slow starts.
In Thursday's affair, which Cleveland won, 7-5, John Danks lasted seven innings, but surrendered seven runs (six earned).
"I lost the game," Danks said afterward. "That's straight up. I lost this game. [We] scored five runs tonight, and that's a good pitcher on the other side. I didn't give us a chance to win this game at all.
"About the only good thing I did was get us through seven. I don't know. I think I'd rather me get through five and giving up a few less than go seven and giving up a ton of runs. It [stinks]. It's getting comical."
The comedy routine Danks mentioned refers to the majority of his six starts this season. In all, he has racked up a 2-4 record and a 6.51 ERA, and he has served up 14 runs (13 earned) on 15 hits in his last two outings.
After compiling a 6.65 ERA in his first four starts, Justin Masterson has pitched better his last two times out. He held the Angels to two runs in 8 1/3 innings on April 27 and earned his first win of the season while opposing Danks on Thursday, when he yielded three runs in 6 1/3 frames.
White Sox: Humber struggling since perfect game
Since hurling his perfect game on April 21, Philip Humber has struggled mightily. The right-hander has allowed 20 earned runs on 21 hits over 13 1/3 innings in three starts since etching his name into the history books.
Humber served up eight runs in a season-low 2 1/3 innings in an 8-6 loss to Cleveland in the first game of Monday's doubleheader.
"I'm not getting down on myself," Humber said. "I know I have what it takes to pitch well. It's just a matter of time for it to happen."
Jose Quintana made his Major League debut Monday after being called up from Double-A Birmingham earlier in the day. He served as the club's 26th player for the day. A new league rule permits teams to carry an extra player on their roster on the day of a twin bill.
Quintana pitched in relief of Humber and allowed one hit and two walks, striking out three, in 5 2/3 innings.
"He was coming in to limit the damage and did more than that. He did great," Ventura said. "He was keeping them off-balance and he was composed."Following Monday's nightcap, Quintana was sent back to Birmingham.
Indians: Sizemore making progress in rehab
Tribe skipper Manny Acta said outfielder Grady Sizemore, recovering from back surgery, could begin hitting in soft-toss sessions when the Indians begin their next homestand on May 16. Sizemore is eligible to return from the 60-day disabled list on June 3.
Sizemore underwent his sixth surgery in the last four years when he had a procedure done on his lower back on March 1.
Cleveland closer Chris Perez recorded 11 saves in the club's first 15 wins, tied for the fewest number of victories to reach that many saves in franchise history with Doug Jones, who saved 11 of the Tribe's first 15 wins in 1990.
Indians starter Zach McAllister earned his first Major League win in a spot start in the opener of Monday's twin bill. McAllister allowed four runs (two earned) in six innings.