Only this time he's in the visiting clubhouse, and is trying to beat the team that drafted him eight years ago.
Harrell, who was chosen by the White Sox in the fourth round of the 2004 First-Year Player Draft, takes the mound on Sunday for the Astros against Chicago and right-hander Philip Humber in the rubber game of a three-game Interleague series.
The 27-year-old Harrell appeared in 11 games for the White Sox from 2010-11 before being claimed off of waivers by the Astros last July. The right-hander hasn't pitched well lately -- giving up nine runs two starts ago -- but should feel some added excitement against his former team.
"I think so, if he can get amped up any more than he already is," Astros manager Brad Mills said. "It's exciting for him to come back here and have them."
Harrell is facing a White Sox team which, despite winning 12 of its last 16, has struggled on a nine-game homestand. The White Sox were hitting only .237 and getting outscored, 40-29, during that stretch before Saturday's 10-1 win.
"I've seen a lot of their hitters and played with a lot of their guys," Harrell said. "It's just about going out there and executing my game plan, and not worrying that I played with these guys."
Astros: Johnson sick
Third baseman Chris Johnson left Friday's game in the sixth inning with flu-like symptoms, and was initially left behind at the team hotel on Saturday before coming to the ballpark on his own.
"He's in the clubhouse. We did leave him at the hotel until -- I thought we were going to leave him there until 2 -- but he's in the clubhouse now," Mills said. "He walked in when I walked out. We tried to keep him away from being around guys and so forth, but he was pretty sick last night."
Left-hander Fernando Abad is scheduled to pitch an inning of relief on Sunday for Triple-A Oklahoma City in a rehab appearance. Abad has been on the disabled list since May 26 with a right intercostal strain.
White Sox: Humber on the hill
Humber takes the mound for the Sox on Sunday, as he looks to rebound from a difficult outing Tuesday against the Blue Jays in which he threw 37 pitches in the first inning and gave up five runs in five. He has been impressive in five Interleague starts, posting a 2-1 record with a 2.08 ERA.
Following his grand slam on Saturday, Adam Dunn is tied with Harold Baines for 58th place on the all-time list with 385 home runs.
Chicago is 54-23 in Interleague play since 2008, including 26-12 at home.
The White Sox lead the all-time regular-season series with the Astros, 11-9.