Activated from the disabled list after 13 months of rehab from Tommy John Surgery, the A's will give the ball to the left-hander in game two of their series against the Twins.
Anderson recorded a 4.62 ERA while making six rehab starts over the last month. He'll be limited to a pitch count of 100 in Tuesday's start.
"We felt like he's ready," Oakland manager Bob Melvin said. "We feel like this could be a nice little shot in the arm for us. We tried to get this guy ready and back, and when he was ready, we said we'd get him here, because he is so talented. We're looking forward to watching him tomorrow."
The Twins may have snapped a five-game skid with Monday's 7-2 series-opening win, but that doesn't mean they're ready to focus simply on "spoiling" Anderson's start, or any other plans their still-contending opponents may have for the season's remainder.
Minnesota has still lost nine of 11, and has plenty of its own improvements to focus on.
"Right now, it's not even about the other team," manager Ron Gardenhire said. "It's about us getting back to winning ballgames, playing a better brand of baseball ourselves. Pitching, get our offense going again because we are scuffling enough. We can't really worry about the other guys. That's a spoiler role, you start watching and it irritates people more when you play well."
Cole De Vries will be looking to fix his own personal struggles on Tuesday when he starts for the Twins. The rookie right-hander is 0-2 in his last four starts, posting an 8.83 ERA. De Vries also struggled in two previous starts against Oakland this year, going 0-1 with a 6.30 ERA.
Gardenhire will be looking for De Vries to improve his pace after pitching too slow for the skipper's liking in his last start against Detroit on Aug. 15. De Vries was smacked around for four runs on a season-high eight hits in only four innings -- which he needed 84 pitches to get through.
"He misfired a little bit," Gardenhire said. "He threw too many pitches. The pace of the game needs to be better than that. It was too slow."
Twins: Blackburn outrighted to Triple-A
Right-hander Nick Blackburn was outrighted to Triple-A Rochester on Monday. The sinkerballer struggled to the tune of a 7.39 ERA in 19 starts for the Twins this season before being removed from the club's 40-man roster.
Blackburn is still owed $5.5 million by the Twins next season, but assistant general manager Rob Antony said he'll still have to earn a spot on the team.
"As far as next year goes, he's still a member of our organization," Antony said. "I suspect, unless we trade him in the offseason, he'll be back in Spring Training trying to win a job on the club."
Minnesota also outrighted infielder Tsuyoshi Nishioka, who will remain with Rochester. The Twins will recall a starting pitcher on Tuesday to start in Wednesday's series finale against Oakland.
A's: Drew to be in uniform
Former Diamondback Stephen Drew will be in uniform for the A's on Tuesday after Oakland acquired him Monday in exchange for Minor League infielder Sean Jamieson. Drew hit .193 with two home runs and 12 RBIs in 40 games for Arizona this season.
Seth Smith went 2-for-3 in a rehab game for Triple-A Sacramento on Monday. Manager Bob Melvin said Smith could be back with Oakland as soon as Tuesday. He has been on the disabled list since Aug. 3 with a strained left hamstring.
The Twins snapped a three-game losing streak against Oakland with Monday's win.