A San Francisco win would not only give the Giants a bit more of a cushion atop the National League West over the Dodgers but also mark the third series sweep this season between the rivals.
The Giants entered the series a half-game behind the Dodgers, but their last two wins have given them a 1 1/2-game lead in the standings. Tim Lincecum followed up Madison Bumgarner's eight shutout innings on Monday by allowing one run in 5 2/3 innings in Tuesday's 4-1 win, and the Giants are hoping Matt Cain will continue the masterful pitching.
Cain will be following up two strong starts in which he allowed three earned runs in 15 1/3 innings, including an eight-inning gem against the Padres in which he allowed one run on four hits his last time out.
"He throws everything for a strike and just keeps you off balance," Padres catcher Yasmani Grandal said of Cain afterward. "It was real tough laying off changeups low in the zone. That's why he had a seven-inning no-hitter or whatever it was."
The Dodgers will send Chris Capuano to the mound to oppose Cain, and Capuano is coming off a strong outing against the Braves that ended in a loss for the Dodgers. He took a three-hitter and a two-run Dodgers lead into the eighth inning, only to get charged with two runs after inherited runners crossed the plate after he departed.
"I thought about starting with [Ronald Belisario], but Cappy was so good, it's like I'm kicking myself for that," Dodgers manager Don Mattingly said afterward.
Capuano has posted three straight quality starts and will be going for his 12th win, which would be his highest total since 2005.
After Wednesday, the Giants and Dodgers will meet again Sept. 7-9 in San Francisco. They also play the final series of the season, Oct. 1-3 in Los Angeles.
Dodgers: De La Rosa activated from DL
Rubby De La Rosa was activated from the disabled list after more than a year removed from his Tommy John surgery. The Dodgers optioned reliever Javy Guerra to Triple-A Albuquerque to make room on the roster.
Mattingly said that De La Rosa will be used out of the bullpen for the remainder of the season, and De La Rosa said that he expects to be throwing 100 mph again soon.
"He's a power arm," Mattingly said. "He's a guy that is swing-and-miss out of the gate, especially in an inning situation."
Giants: Theriot trying the outfield
With Marco Scutaro having taken his regular job at second base, Ryan Theriot has been working on his outfield skills in order to potentially be an outfield option for the Giants.
"I've always been one of those guys who enjoys doing different things," Theriot said Tuesday. "The key is being able to play it effectively."
Theriot has made six appearances in the outfield in his career, including a two-inning appearance against the Rockies on April 11. Giants manager Bruce Bochy said he would keep all options open for filling Melky Cabrera's spot in left field after the All-Star was suspended 50 games for performance-enhancing drugs.
The Giants head into the final game of their six-game road trip with a 4-1 record.
The Dodgers are 6-11 at home since the All-Star break.
Capuano is 1-5 with a 5.00 ERA in 10 career games (six starts) against the Giants.
The Giants are 13-2 when they score three or more runs behind Cain, and he is 11-0 in such games.