Only three American League teams have more home wins than Detroit, which will be looking for its second sweep of the month in Thursday's series finale.
The club should feel extremely confident with its chances, as it turns to ace Justin Verlander, who is 12-7 with a 2.53 ERA.
Verlander, the reigning AL MVP and Cy Young Award winner, is once again among the leaders in nearly every pitching category, and he no-hit the Blue Jays the last time he faced them, on May 7, 2011.
Runs usually come at a premium with Verlander on the mound, and he will be going up against an offense that has been struggling of late. Toronto has scored just 13 runs in its past six games, and more than five just once over its last 10.
The right-hander, who has gone 1-2 over his past five starts, will be opposed by Blue Jays lefty J.A. Happ -- the third southpaw to start against Detroit this series.
Happ has made just three starts with Toronto since being acquired in July, but he is coming off his best one.
He threw six innings of two-hit ball against the Rangers and struck out eight, including six consecutive to match a club record.
The 29-year-old, who will be looking to extend his win streak to three games, prefers to start, something he has done for the majority of his career before his temporary stay in Toronto's bullpen.
"I'm feeling much better," Happ said. "It's nice to get back on a routine. In our minds, it's a little different being in the bullpen a little while. I'm definitely in a better place physically as a starter."
The Blue Jays have lost five consecutive series. The last time Toronto won a series came against the Tigers from July 27-29 in Toronto.
Blue Jays: Torrealba plays first game with Toronto
Yorvit Torrealba, who the Blue Jays signed on Aug. 14 after he was was released by the Rangers, made his debut for Toronto in Wednesday's loss.
The 12-year veteran went 1-for-3 with a walk and a run scored.
Torrealba will split catching duties with Jeff Mathis until injured starter J.P. Arencibia returns. Arencibia, who landed on the disabled list in late July with a fractured right hand, is expected to be back some time in September.
Rajai Davis swiped his 39th stolen base on Wednesday, which tied the Major League lead. The speedster needs one more stolen base to reach 40 for the third time in his career. His career high is 50, coming in 2010 as a member of the A's.
David Cooper is day to day after jamming his neck in the fourth inning of Wednesday's game.
The 25-year-old had been filling in admirably during first baseman's Adam Lind's absence, hitting .329 (23-70) over 19 games in August. Of the 23 hits, 10 have gone for extra bases, which ranked seventh in the AL this month entering Wednesday's contest.
"He has proven that he can hit Major League pitching," Blue Jays manager John Farrell said about Cooper, who has just 211 at-bats at in the big leagues. "He doesn't strike out, he's able to go the other way, he's able to stay in on left-handers, his track record shows that."
Tigers: Valverde reaches save milestone
Closer Jose Valverde became the fifth player in Tigers history to record 100 saves.
Valverde reached the mark by picking up his 25th save of the season in Wednesday's victory.
It was also the 267th of his career, which moved him into a tie with Bob Wickman for 28th on the all-time list.
With a first-inning strikeout by Anibal Sanchez on Wednesday, Tigers pitchers reached 1,000 on the year for the 13th time in club history.
Prince Fielder drove in his 89th run of the season with a sixth-inning single on Wednesday. Fielder and Miguel Cabrera are the only duo in the AL with 80 or more RBIs.
Other than Omar Vizquel, the only Blue Jays with more than one hit against Verlander are currently not with the team. Jose Bautista and Adam Lind are on the disabled list and Yunel Escobar is on the paternity list.
Fielder is 6-for-16 in his career against Happ, with three doubles and four RBIs.
Toronto has lost 10 of its past 12 games on the road, and four straight overall.