SEATTLE -- The Oakland Athletics scored four runs in the top of the eighth inning to come back and beat the Seattle Mariners, 4-2, Sunday afternoon at Safeco Field.

Seattle starter Felix Hernandez fired seven shutout innings before running into trouble in the eighth frame. Walks to Jack Hannahan and Daric Barton around a Mark Ellis double loaded the bases for Emil Brown. The Oakland right fielder delivered a two-run single on Hernandez's 115th, and final, pitch of the afternoon to score a pair and erase Seattle's 2-0 lead.

""I felt good, for nothing," a clearly disappointed Hernandez said after the loss. "[It] was a tough loss. [I] was working hard and pitched pretty good for nothing. We lost the game. I tried to make my pitches in the eighth, but I left that curveball hanging and [Brown] hit it pretty good."

"Felix pitched well, but the eighth inning was tough on us," manager John McLaren said. "He was still strong, he just didn't get some pitches there in the end."

Brandon Morrow didn't provide much relief for the Mariners. The right-hander walked Frank Thomas to load the bases for the second time in the inning before allowing a run-scoring single to Jack Cust. After striking out Bobby Crosby, Ryan Sweeney delivered an opposite-field RBI single to give Oakland a two-run lead.

Hernandez finished the game allowing four runs on six hits and struck out 10 to increase his American League-leading strikeout total to 41.

The loss snapped Hernandez's career-best six-game winning streak.

"Everything was working all game long," Hernandez added. "Those guys made adjustments, and [it was a] tough loss. I had the lead, two-nothing. I have to hang in there, but can't."

The 22-year-old right-hander breezed through the first three innings, facing the minimum nine batters while striking out five. Oakland threatened in the fourth, loading the bases with one out on three singles, but Hernandez escaped the jam by striking out Cust and getting a fielder's choice groundout to third base off the bat of Crosby.

Hernandez was in another jam an inning later after walking back-to-back batters with one out, but he responded by striking out Ellis and Barton to end the inning and start a stretch where he retired eight straight Oakland hitters.

Seattle opened the scoring in the bottom of the first inning. Jose Lopez dropped a one-out double between left fielder Cust and Sweeney in center field. Adrian Beltre followed with a two-out RBI single to left field to give Seattle an early 1-0 lead.

Yuniesky Betancourt doubled the lead in the fourth when he lined a 1-0 pitch from Oakland starter Joe Blanton into the Athletics' bullpen for his first home run of the season.

Seattle finished the six-game homestand with a 2-4 record, dropping series to Baltimore and Oakland.

"It wasn't a good homestand," McLaren said. "We've just got to pick ourselves up and keep going. There's some positives, but we're still not running on all cylinders. We got too many guys that still aren't swinging the bats well, and we're not driving in runs when they're out there."